We use the construction of unfolded Seiberg-Witten Floer spectra of general 3-manifolds defined in our previous paper to extend the notion of relative Bauer-Furuta invariants to general 4-manifolds with boundary. One of the main purposes of this paper is to give a detailed proof of the gluing theorem for the relative invariants.

Kronheimer-Mrowka recently proved that the Dehn twist along a 3-sphere in the neck of K3#K3 is not smoothly isotopic to the identity. This provides a new example of self-diffeomorphisms on 4-manifolds that are isotopic to the identity in the topological category but not smoothly so. (The first such examples were given by Ruberman.) In this paper, we use the Pin(2)-equivariant Bauer-Furuta invariant to show that this Dehn twist is not smoothly isotopic to the identity even after a single stabilization (connected summing with the identity map on S2×S2). This gives the first example of exotic phenomena on simply connected smooth 4-manifolds that do not disappear after a single stabilization.

In studying the "11/8-Conjecture" on the Geography Problem in 4-dimensional topology, Furuta proposed a question on the existence of Pin(2)-equivariant stable maps between certain representation spheres. In this paper, we present a complete solution to this problem by analyzing the Pin(2)-equivariant Mahowald invariants. As a geometric application of our result, we prove a "10/8+4"-Theorem. We prove our theorem by analyzing maps between certain finite spectra arising from BPin(2) and various Thom spectra associated with it. To analyze these maps, we use the technique of cell diagrams, known results on the stable homotopy groups of spheres, and the j-based Atiyah-Hirzebruch spectral sequence.