This talk will give a very brief outline how a portion of geometric analysis was carried out in relation to geometry, nonlinear partial differential equations and mathematical physics. My personal experience is that this is a beautiful subject with great depth and it touches almost all branch of mathematics.

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No abstract uploaded!

We introduce new boundary conditions for differential forms on symplectic manifolds with boundary. These boundary conditions, dependent on the symplectic structure, allows us to write down elliptic boundary value problems for both second-order and fourth-order symplectic Laplacians and establish Hodge theories for the cohomologies of primitive forms on manifolds with boundary. We further use these boundary conditions to define a relative version of the primitive cohomologies and to relate primitive cohomologies with Lefschetz maps on manifolds with boundary. As we show, these cohomologies of primitive forms can distinguish certain Kahler structures of Kahler manifolds with boundary.

Analyzing phylogenetic relationships using mathematical methods has always been of importance in bioinformatics. Quantitative research may interpret the raw biological data in a precise way. Multiple Sequence Alignment (MSA) is used frequently to analyze biological evolutions, but is very time-consuming. When the scale of data is large, alignment methods cannot finish calculation in reasonable time. Therefore, we present a new method using moments of cumulative Fourier power spectrum in clustering the DNA sequences. Each sequence is translated into a vector in Euclidean space. Distances between the vectors can reflect the relationships between sequences. The mapping between the spectra and moment vector is one-to-one, which means that no information is lost in the power spectra during the calculation. We cluster and classify several datasets including Influenza A, primates, and human rhinovirus (HRV) datasets to build up the phylogenetic trees. Results show that the new proposed cumulative Fourier power spectrum is much faster and more accurately than MSA and another alignment-free method known as k-mer. The research provides us new insights in the study of phylogeny, evolution, and efficient DNA comparison algorithms for large genomes. The computer programs of the cumulative Fourier power spectrum are available at GitHub (https://github.com/YaulabTsinghua/cumulative-Fourier-power-spectrum).