Adult stem cells, which exist throughout the body, multiply by cell division to replenish dying cells or to promote regeneration to repair damaged tissues. To perform these functions during the lifetime of organs or tissues, stem cells need to maintain their populations in a faithful distribution of their epigenetic states, which are suscepti- ble to stochastic fluctuations during each cell division, unexpected injury, and potential genetic mutations that occur during many cell divisions. However, it remains unclear how the three processes of differentiation, proliferation, and apoptosis in regulating stem cells collectively manage these challenging tasks. Here, without consid- ering molecular details, we propose a genetic optimal control model for adult stem cell regeneration that includes the three fundamental processes, along with cell division and adaptation based on differ- ential fitnesses of phenotypes. In the model, stem cells with a distri- bution of epigenetic states are required to maximize expected performance after each cell division. We show that heteroge- neous proliferation that depends on the epigenetic states of stem cells can improve the maintenance of stem cell distributions to create balanced populations. A control strategy during each cell division leads to a feedback mechanism involving heterogeneous proliferation that can accelerate regeneration with less fluctuation in the stem cell population. When mutation is allowed, apoptosis evolves to maximize the performance during homeostasis after multiple cell divisions. The overall results highlight the importance of cross-talk between genetic and epigenetic regulation and the performance objectives during homeostasis in shaping a desirable heterogeneous distribution of stem cells in epigenetic states.

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We propose a variational approach to obtain superresolution images from multiple low-resolution frames extracted from video clips. First the displacement between the lowresolution frames and the reference frame are computed by an optical flow algorithm. Then a low-rank model is used to construct the reference frame in high-resolution by incorporating the information of the low-resolution frames. The model has two terms: a 2-norm data fidelity term and a nuclear-norm regularization term. Alternating direction method of multipliers is used to solve the model. Comparison of our methods with other models on synthetic and real video clips show that our resulting images are more accurate with less artifacts. It also provides much finer and discernable details.

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In this paper, we construct a new suboptimal filter by deriving the Ito's stochastic differential equations of the estimation of higher order central moments satisfy and imposing some conditions to form a closed system. The essentially infinite-dimensional cubic sensor problem has been investigated in detail numerically to illustrate the reasonableness of the imposed conditions, and the numerical experiments support our discussion. A 2-dimensional polynomial filtering problem has also been experimented.