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Let X be a compact K\" ahler manifold and X be a simple normal crossing divisor. If X is the support of some effective X -ample divisor, we show <div class="gsh_dspfr"> X

In this paper, we study the existence of homoclinic solutions for a class of fourth order differential equations. By using variational methods, the existence and the non-existence of nontrivial homoclinic solutions are obtained, depending on a parameter.

The interplay between excitatory and inhibitory neurons imparts rich functions of the brain. To understand the synaptic mechanisms underlying neuronal computations, a fundamental approach is to study the dynamics of excitatory and inhibitory synaptic inputs of each neuron. The traditional method of determining input conductance, which has been applied for decades, employs the synaptic current-voltage (I-V) relation obtained via voltage clamp. Due to the space clamp effect, the measured conductance is different from the local conductance on the dendrites. Therefore, the interpretation of the measured conductance remains to be clarified. Using theoretical analysis, electrophysiological experiments, and realistic neuron simulations, here we demonstrate that there does not exist a transform between the local conductance and the conductance measured by the traditional method, due to the neglect of a nonlinear interaction between the clamp current and the synaptic current in the traditional method. Consequently, the conductance determined by the traditional method may not correlate with the local conductance on the dendrites, and its value could be unphysically negative as observed in experiment. To circumvent the challenge of the space clamp effect and elucidate synaptic impact on neuronal information processing, we propose the concept of effective conductance which is proportional to the local conductance on the dendrite and reflects directly the functional influence of synaptic inputs on somatic membrane potential dynamics, and we further develop a framework to determine the effective conductance accurately. Our work suggests re-examination of previous studies involving conductance measurement and provides a reliable approach to assess synaptic influence on neuronal computation.

We consider Hermitian random band matrices $H=(h_{xy})$ on the $d$-dimensional lattice $(\Z/L\Z)^d$. The entries $h_{xy}$ are independent (up to Hermitian conditions) centered complex Gaussian random variables with variances $s_{xy}=\mathbb E|h_{xy}|^2$. The variance matrix $S=(s_{xy})$ has a banded structure so that $s_{xy}$ is negligible if $|x-y|$ exceeds the band width $W$. In dimensions $d\ge 8$, we prove that, as long as $W\ge L^\e$ for a small constant $\e>0$, with high probability most bulk eigenvectors of $H$ are delocalized in the sense that their localization lengths are comparable to $L$. Denote by $G(z)=(H-z)^{-1}$ the Green's function of $H$. For $\im z\gg W^2/L^2$, we also prove a widely used criterion in physics for quantum diffusion of this model, namely, the leading term in the Fourier transform of $\E|G_{xy}(z)|^2$ with respect to $x-y$ is of the form $(\im z + a(p))^{-1}$ for some $a(p)$ quadratic in $p$, where $p$ is the Fourier variable. Our method is based on an expansion of $T_{xy}=|m|^2 \sum_{\alpha}s_{x\alpha}|G_{\alpha y}|^2$ and it requires a self-energy renormalization up to error $W^{-K}$ for any large constant $K$ independent of $W$ and $L$. We expect that this method can be extended to non-Gaussian band matrices.

Fusion of images with same or different modalities has been conquering medical imaging field more rapidly due to the presence of highly accessible patients’ information in recent years. For example, cross platform non-rigid registration of CT with MRI images has found a significant role in different clinical application. In some instances labelling of anatomical features by medical experts are also involved to further improve the accuracy and authenticity of the registration. Being motivated by these, we propose a new algorithm to compute diffeomorphic hybrid multi-modality registration with large deformations. Our iterative scheme consists of mainly two steps. First, we obtain the optimal Beltrami coefficient corresponding to the diffeomorphic mapping that exactly superimposes the feature points. The second step detects the intensity difference in the framework of mutual information. A non-rigid deformation which minimizes the intensity difference is then obtained. Experiments have been carried out on both synthetic and real data. Results demonstrate the stability and efficacy of the proposed algorithm to obtain diffeomorphic image registration.

Let M 4n be a complete quaternionic K¨ahler manifold with scalar curvature bounded below by .16n(n + 2). We get a sharp estimate for the first eigenvalue λ1(M) of the Laplacian, which is λ1(M) ≤ (2n + 1)2. If the equality holds, then either M has only one end, or M is diffeomorphic to R × N with N given by a compact manifold. Moreover, if M is of bounded curvature, M is covered by the quaterionic hyperbolic space QHn and N is a compact quotient of the generalized Heisenberg group. When λ1(M) ≥ 8(n+2) 3 , we also prove that M must have only one end with infinite volume.

In this article we show how the classical theory of Reeb and others extends to the case of codimension one singular foliations on closed oriented manifolds, provided that at the singular set sing(F), the foliation is locally defined by Bott-Morse functions which are transversely centers. We prove, in this setting, the equivalent of the local and the complete stability theorems of Reeb. We show that if F has a compact leaf with finite fundamental group, or if a component of sing(F) has codimension ≥ 3 and finite fundamental group, then all leaves of F are compact and diffeomorphic, sing(F) consists of two connected components, and there is a Bott-Morse function f : M → [0, 1] such that f : M \ sing(F) → (0, 1) is a fiber bundle defining F and sing(F) = f.1({0, 1}). This yields a topological description of the type of leaves that appear in these foliations, and also the type of manifolds admitting such foliations. These results unify and generalize well known results for cohomogeneity one isometric actions, and a theorem of Reeb for foliations with Morse singularities of center type.

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We show that in a tubular domain with sufficiently small width, the normal and tangential gradients of a harmonic function have almost the same L 2 norm. This estimate yields a sharp estimate of the pressure in terms of the viscosity term in the Navier-Stokes equation with no-slip boundary condition. By consequence, one can analyze the Navier-Stokes equations simply as a perturbed vector diffusion equation instead of as a perturbed Stokes system. As an application, we describe a rather easy approach to establish a new isomorphism theorem for the non-homogeneous Stokes system.

We study analytic integrable deformations of the germ of a holomorphic foliation given by df=0 at the origin 0∈Cn,n≥3. We consider the case where f is a germ of an irreducible and reduced holomorphic function. Our central hypotheses is that, outside of a dimension ≤n−3 analytic subset Y⊂X, the analytic hypersurface Xf:(f=0) has only normal crossings singularities. We then prove that, as germs, such deformations also exhibit a holomorphic first integral, depending analytically on the parameter of the deformation. This applies to the study of integrable germs writing as ω=df+fη where f is quasi-homogeneous. Under the same hypotheses for Xf:(f=0) we prove that ω also admits a holomorphic first integral. Finally, we conclude that an integrable germ ω=adf+fη admits a holomorphic first integral provided that: (i) Xf:(f=0) is irreducible with an isolated singularity at the origin 0∈Cn,n≥3; (ii) the algebraic multiplicities of ω and f at the origin satisfy ν(ω)=ν(df). In the case of an isolated singularity for (f=0) the writing ω=adf+fη is always assured so that we conclude the existence of a holomorphic first integral. Some questions related to Relative Cohomology are naturally considered and not all of them answered.

Estimation of genewise variance arises from two important applications in microarray data analysis: selecting significantly differentially expressed genes and validation tests for normalization of microarray data. We approach the problem by introducing a two-way nonparametric model, which is an extension of the famous Neyman-Scott model and is applicable beyond microarray data. The problem itself poses interesting challenges because the number of nuisance parameters is proportional to the sample size and it is not obvious how the variance function can be estimated when measurements are correlated. In such a high-dimensional nonparametric problem, we proposed two novel nonparametric estimators for genewise variance function and semiparametric estimators for measurement correlation, via solving a system of nonlinear equations. Their asymptotic normality is established. The finite sample property is

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In this paper we study the geometry of manifolds with vector cross products and its complexification. First we develop the theory of instantons and branes and study their deformations. For example they are (i) holomorphic curves and Lagrangian submanifolds in symplectic manifolds and (ii) associative submanifolds and coassociative submanifolds in G2-manifolds. Second we classify K¨ahler manifolds with the complex analog of the vector cross product, namely they are Calabi-Yau manifolds and hyperk¨ahler manifolds. Furthermore we study instantons, Neumann branes and Dirichlet branes on these manifolds. For example they are special Lagrangian submanifolds with phase angle zero, complex hypersurfaces and special Lagrangian submanifolds with phase angle pi/2 in Calabi-Yau manifolds.

We show that the interior of the convex core of a quasifuchsian punctured-torus group admits an ideal decomposition (usually an infinite triangulation) which is canonical in two very different senses: in a combinatorial sense via the pleating invariants, and in a geometric sense via an Epstein-Penner convex hull construction in Minkowski space. This result re-proves the Pleating Lamination Theorem for quasifuchsian punctured-torus groups, and extends to all punctured-torus groups if a strong version of the Pleating Lamination Conjecture is true.